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Targeting Angiogenesis: VEGF Signaling Inhibition

Evaluation of VEGF signaling inhibition

VEGFR

Inhibition of VEGF signaling interferes with the pivotal angiogenic process that is required for all solid tumor growth. VEGFR signaling is critical for blood vessel formation and is involved in all stages of angiogenesis, some facets of vasculogenesis, as well as the induction of vascular permeability.1,2

VEGFs bind to, and activate, the cell-surface receptors VEGFR-1 (Flt-1),
VEGFR-2 (KDR), and VEGFR-3 (Flt-4). 

VEGFR-1 and VEGFR-2 have roles in mediating VEGF-induced responses in endothelial cells, while VEGFR-3 has been identified as having a critical role in lymphangiogenesis, which is believed to be important in the spread of metastases.1-3 Inhibition of VEGFR signaling is therefore an attractive therapeutic target in a wide range of tumors.

VEGFR-TK Inhibition – AstraZeneca Oncology.com

Inhibition of VEGF signaling interferes with the pivotal angiogenic process that is required for all solid tumor growth. Learn how inhibition of VEGF signaling via VEGFR-TK Inhibition may impact cancer. Click the play button below.


 

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References
  1. Ferrara N, Gerber H-P, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9:669-676.
  2. Risau W. Mechanisms of angiogenesis. Nature. 1997;386:671-674.
  3. Dvorak HF, Detmar M, Claffey KP, Nagy JA, van de Water L, Senger DR. Int Arch Allergy Immunol.1995;107:233-235.