Oncology research has been a priority at AstraZeneca since the 1960s. Since that time, we have evaluated numerous drugs for the treatment of a range of cancers and we continue to do so today. Currently, we are investigating several different signaling pathways to evaluate their potential for the treatment of cancer. We invite you to explore these approaches or review our current pipeline.
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Phases of development |
| Research target |
Mechanism of action |
Compound |
Preclinical |
I |
II |
III |
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| Anti-angiogenesis and antiproliferation |
VEGFR, EGFR, and RET tyrosine kinase inhibition |
Vandetanib |
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| Anti-angiogenesis |
VEGF signaling inhibition |
Cediranib |
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| Endothelin A receptor antagonist |
Specific endothelin A receptor inhibition |
Zibotentan
(ZD4054) |
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| Antiproliferation |
MEK 1/2 inhibition |
AZD6244
(ARRY-
142886†) |
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| Inhibition of DNA repair |
PARP inhibition |
Olaparib
(AZD2281*) |
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| Antiproliferation |
Aurora kinase inhibition |
AZD1152 |
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| Inhibition of DNA repair |
Chk1 inhibition |
AZD7762 |
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| Antiproliferation and promotion of cell death |
Inhibition of erbB1, erbB2, and erbB3 receptor signaling |
AZD8931 |
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| Antiproliferation |
mTORC1 and mTORC2 kinase inhibition |
AZD8055 |
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Chk1, checkpoint kinase 1; EGFR, epidermal growth factor receptor; MEK, mitogen-activated protein kinase kinase; mTORC, mammalian target of rapamycin complex; PARP, Poly (ADP-ribose) polymerase; RET, rearranged during transfection; VEGFR, vascular endothelial growth factor receptor.
†In-licensed from ARRAY BioPharma.
*AZD2281, previously known as KU-0059436, was incorporated into the pipeline following the acquisition of KuDOS Pharmaceuticals Ltd. KuDOS Pharmaceuticals Ltd is a wholly owned subsidiary of AstraZeneca plc. |
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